Semaphorin 4D from CD15+ Granulocytes via ADAM10-Induced Cleavage Contributes to Antibody Production in Bullous Pemphigoid

Trauma-induced bullous pemphigoid

Indian J Dermatol Venereol Leprol | November-December 2009 | Vol 75 | Issue 6 Both ELISA and WB results were consistent for different storage periods (up to 10 days), suggesting that antibodies from sera collected on filter paper can remain stable. Stability of antibodies reactive to viral antigens of diagnostic importance was further tested with two of these samples for a 15-days storage perio...

Carbamazepine-induced bullous eruption or bullous pemphigoid?

Mefenamic acid-induced bullous pemphigoid.

A 52 year old man developed bullous pemphigoid, Coombs' positive haemolytic anaemia and diarrhoea related to the use of mefenamic acid. Clinical manifestation of the bullous pemphigoid, haemolytic anaemia and diarrhoea resolved following discontinuation of the mefenamic acid. Mefenamic acid should be added to the list of agents that are known to induce bullous pemphigoid.

PUVA-induced Bullous Pemphigoid in Psoriasis.

The association between psoriasis vulgaris and bullous pemphigoid is due to the still unclear autoimmune process. The common disease site is the dermo-epidermal junction or basal membrane zone (BMZ), with specific alterations for both diseases. Photochemotherapy (PUVA) is one of the therapeutic modalities for psoriasis and can trigger production of autoantibodies against antigens in the BMZ in ...

Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications

OBJECTIVE Semaphorin 4D (Sema4D)/CD100 has pleiotropic roles in immune activation, angiogenesis, bone metabolism, and neural development. We undertook this study to investigate the role of Sema4D in rheumatoid arthritis (RA). METHODS Soluble Sema4D (sSema4D) levels in serum and synovial fluid were analyzed by enzyme-linked immunosorbent assay. Cell surface expression and transcripts of Sema4D...